金天如
现任加拿大多伦多大学医学系生理学研究室，教授。
主要研究糖脂代谢紊乱相关疾病的发病机制，特别是在胰高血糖素样肽一1(glucagon-likepeptide1，GLP-1)表达和功能调控方面具有较高国际影响力，另外对膳食多酚改善胰岛素抵抗也进行了系统研究。
担任Am. Journal of Physiology (Endo/Metab)、Journal of Endocrine Society、Plos One、 Obesity Medicine等多个国际期刊编委。
主要科研项目
2018 – 2023 Principal Investigator. Metabolic functions of the Wnt signaling pathway. Canadian Institutes of Health Research (CIHR). Project Grant. 772,650 CAD. [Grants]
2018 Jul – 2019 Jun Principal Investigator. Novel role of glucagon-like-peptide-1 receptor: Mediating function of gamma-Aminobutyric acid (GABA). Banting & Best Diabetes Centre. Pilot and Feasibility Grant. 40,000 CAD. [Grants]
2017 Sep – 2019 Aug Co-Principal Investigator. Oral therapy for the regeneration and protection of human pancreatic beta cells and treatment of type 1 diabetes. Juvenile Diabetes Research Foundation. PI: Dr. Gerald Prud’homme. Collaborator(s): Dr. Qinghua Wang. 500,000 USD. [Grants]
2016 Jul – 2017 Jun Principal Investigator. A novel mechanism for controlling adipogenesis: The role of the microRNA miR-17. Banting & Best Diabetes Centre. Sun Life Financial Pilot and Feasibility. Collaborator(s): Dr. Burton Yang (Co-investigator). 50,000 CAD. [Grants]
2015 Jun – 2017 May Co-Principal Investigator. Effects of GABA and GLP-1 combined therapy in promoting regeneration and survival of human islet beta cells. Juvenile Diabetes Research Foundation. 2-SRA-2015-64-Q-R. PI: Dr. Qinghua Wang. Collaborator(s): Dr. Gerald Prud’homme. 250,000 USD. [Grants]
2013 Jan – 2015 Dec Co-Investigator. Neutraceuticals and diabetes: Nrf-2 activation is a critical mechanism underlying the effect of certain plant-derived compounds in preventing insulin resistance. Canadian Institutes of Health Research (CIHR). China Canada Research Initiative. PI: Fantus, George I. Collaborator(s): Dr. Jianping Weng. 225,000 CAD. [Grants]
Joint biomedical research program by CIHR and National Natural Science Foundation of China (NSFC).
主要论著（*为通讯作者）
1.Zhang Y, Thai K, Jin T, Woo M, Gilbert RE. SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice. Sci Rep. 2018 Sep 18;8(1):13972. doi: 10.1038/s41598-018-32351-z.
2.Shao W, Szeto V, Song Z, Tian L, Feng Z-P, Nostro MC, Jin T. The LIM homeodomain protein ISL1 mediates the function of TCF7L2 in pancreatic beta cells. J Mol Endocrinology. 2018 61(1):1-12.
3.Jin TR. Curcumin and dietary polyphenol research: beyond drug discovery. Acta Pharmacologica Sinica. 2018 May;39(5):779-786.
4.Song Z, Revelo X, Shao W, Tian L, Zeng K, Lei H, Sun H-S, Woo M, Winer D, Jin T. Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression. Obesity (Silver Spring). 2018. 26(3):547-558.
5.Jin T, Song Z, Weng J, Fantus IG. Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity. Am J Physiol Endocrinol Metab. 2018 Mar 1;314(3):E201-E205.
6.Zeng K, Tian L, Sirek A, Shao W, Liu L, Chiang YT, Chernoff J, Ng DS, Weng J, Jin T. Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression. J Mol Cell Biol. 2017 Oct 1;9(5):384-394.
7.Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Hui Yng Chng M, Shen L, D’Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer D . Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome. Science Immunology.2017 Apr 21;2(10).
8.Liu W, Son DO, Lau HK, Zhou Y, Prud’homme GJ, Jin T, Wang Q. Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice. Front Pharmacol. 2017 Jun 20;8:362.
9.Tian L, Song Z, Shao W, Du WW, Zhao LR, Zeng K, Yang BB, Jin T. Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signaling pathway effector Tcf7l2. Cell Death and Disease. 2017 Jan 19;8(1):e2559.
10.Zeng K, Tian L, Patel R, Shao W, Song Z, Liu L, Manuel J, Ma X, McGilvray I, Cummins CL, Weng J, Jin T. Diet polyphenol curcumin stimulates hepatic Fgf21production and restores its sensitivity in high fat diet fed male mice. Endocrinology. 2017 Feb 1;158(2):277-292.
11.Tian L, Jin T. The incretin hormone GLP-1 and mechanisms underlying its secretion. J. Diabetes. 2016. 8(6): 753-765.
12.Liu R, Wang H, Xu B, Chen W, Turlova E, Dong N, Sun C, Lu Y, Fu H, Shi R, Barszczyk A, Yang D, Jin T, Mannucci E, Feng ZP, Sun HS. Cerebrovascular Safety of Sulfonylureas: The Role of KATP Channels in Neuroprotection and the Risk of Stroke in Patients With Type 2 Diabetes. Diabetes. 2016 Sep;65(9):2795-809.
13.Jin T, Weng J. Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives. Am J Physiol Endocrinol Metab. 2016 Sep. 311(3): E620-7.
14.Revelo XS, Ghazarian M, Chng MH, Luck H, Kim JH, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Liu CL, Tangsombatvisit S, Tsui H, Sima C, Xiao C, Shen L, Li X, Jin T, Lewis GF, Woo M, Utz PJ, Glogauer M, Engleman E, Winer S, Winer DA. Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance. Cell Report. 2016 Jul;16(3):717-30.
15.Jin T. Incretin hormone glucagon-like peptide-1 and gut microbiota -current knowledge and perspectives. Chin. J Pharmacol. Toxicol. 2016 Jun30(6): 691-702.
16.Jin T. Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose Homeostasis. Endocrine Review. 2016 Jun;37(3):254-77.
17.Tian L, Zeng K, Shao W, Yang BB, Fantus GI, Weng J, Jin T. Short-Term Curcumin Gavage Sensitizes Insulin Signaling in Dexamethasone-Treated C57BL/6 Mice. Journal of Nutrition. 2015 Oct;145(10):2300-7.
18.Du WW, Liu F, Shan SW, Ma XC, Gupta S, Jin T, Spaner D, Krylov SN, Zhang Y, Ling W, Yang BB. Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. Molecular Therapy. 2015 Jul;23(7):1222-33.
19.Ip W, Shao W, Song Z, Chen Z, Wheeler MB, Jin T. Liver-specific Expression of Dominant Negative Transcription Factor 7-like 2 Causes Progressive Impairment in Glucose Homeostasis. Diabetes. 2015 Jun;64(6):1923-32.
20.Chen ZL, Shao WJ, Xu F, Liu L, Lin BS, Wei XH, Song ZL, Lu HG, Fantus IG, Weng JP, Jin TR. Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes. Cell Signal. 2015 Mar;27(3):587-97.