徐爱民

香港大学药物生物技术国家重点实验室主任，香港大学抗体及免疫检测服务主任。

徐愛民教授主要從事針對肥胖、糖尿病及相關心血管併發症的研究及相關醫藥技術開發。他發現了抗糖尿病激素脂聯素的活性體，並率先揭示了脂聯素對脂肪肝及血管疾病的保護作用。在過去十多年，其團隊陸續發現並鑒定了多種與肥胖、糖尿病及心血管代謝綜合症發病原因有密切關係的脂肪分泌激素，研發成生物標誌物及相關檢測產品，用於上述慢性疾病的風險預測、早期分型診斷及治療評估。最近，他的團隊亦發現肝臟分泌的激素FGF21通過調節脂聯素，可被用作治療因肥胖而致的動脈粥樣硬化的潛在藥物。

主要社会兼职

Biochemical Journal副主编

美国糖尿病协会会员

美国生物化学和分子生物学学会HBHA中心会员

担任《PLOS One》，《Journal of Obesity》，《Journal of Diabetes》，《Adipocytes》，《Cardiovascular》，《Drugs and Therapy》等国际期刊编辑；

主要研究项目

1.RGC Collaborative Research Fund (C7055-14G) – PI

2.A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention

3.ITC University-industrial matching fund (UIM/270) -PI

4.Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications

5.NSFC/RGC Joint Research Scheme (N_HKU726/14) – PI

6.Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance

7.General Research Fund (HKU17124714) – PI

8.Interplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues

9.France ANR/RGC research Scheme (A-HKU-705/13) – PI

10.The gut microbiota-adipose tissue axis in the pathogenesis of obesity and its related metabolic disorders: molecular mechanism and clinical implications

11.General Research Fund (HKU783413M) – PI

12.Fibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain

13.National Key Basic Research Development Program – 973 Program – Co-PI

14.The Metabolic Syndrome in Chinese: from molecular mechanism to therapeutic intervention

代表性论著

1.Hui X, Gu P, Zhang J, Nie T, Pan Y, Wu D, Feng T, Zhong C, Wang Y, Lam KSL, Xu A*. Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 2015 Aug 4; 22(2):279-290.

2.Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X*, Xu A*. Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. Circulation. 2015 Mar 26;131(21):1861-71.

3.Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, Xu A*, So KF*. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15810-5.

4.Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KSL*, Xu A*. Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice. Hepatology. 2014 Sep;60(3):977-89. (Selected for commentary @ Fibroblast growth factor 21: a new liver safeguard. [Hepatology. 2014])

5.Wang Y, Xiao Y, Zhong L, Ye D, Zhang J, Tu Y, Bornstein SR, Zhou Z*, Lam KS*, Xu A*. Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated with β-cell Autoimmunity in Patients with Type 1 Diabetes. Diabetes. 2014 Dec;63(12):4239-48 . (Selected for commentary @ Autoimmune diabetes: caught in a NET. [Diabetes. 2014])

6.Cheng KKY*, Zhu W, Chen B, Wang Y, Wu D, Sweeney G, Wang B, Lam KSL, Xu A*, The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes, 2014 Nov;63(11):3748-58.

7.Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KSL*, Xu A*. FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting. Diabetes. 2014 Dec;63(12):4064-75 (Selected for commentary @ Head over hepatocytes for FGF21. [Diabetes. 2014])

8.Lin Z, Wu F, Lin S, Pan X, Jin L, Lu T, Shi L, Wang Y, Xu A*, Li X*. Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. J Hepatol, 2014 Oct;61(4):825-31

9.Hoo RLC, Lee IPC, Zhou M, Wong JYL, Hui X, Xu A*, Lam KSL*. Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice. J Hepatol. 2013 Feb;58(2):358-64.

10.Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A*, Li X*. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metabolism. 2013;17:779-89 (Cited ~100 times)

11.Cheng KK, Lam KS, Wu D, Wang Y, Xu A*. APPL1 potentiates insulin secretion in pancreatic beta-cells by increasing Akt-dependent expression of SNARE proteins in mice. Proc. Natl. Acad. Sci. USA. 2012 Jun 5;109(23):8919-24. (Selected for commentary@ Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion. [Proc Natl Acad Sci U S A. 2012])

12.Li FY, Lam KS, Tse HF, Chen C, Wang Y, Vanhoutte PM, Xu A*. Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice. Circulation. 2012 Sep 4;126(10):1267-77.

13.Ye D, Li Y, Lam KS, Li H, Jia W, Wang Y, Man K, Li X, Xu A*. TLR4 mediates obesity-induced nonalcoholic steatohepatitis through activation of X-box binding protein in mice. Gut. 2012 Jul; 61(7): 1058-67.